Evaluation of the Use of Sitagliptin for Insulin Resistance in Burn Patients
Objective
This retrospective review compares exogenous insulin requirements before and after sitagliptin initiation as well as time to liberation from intravenous insulin infusion (managed with EndoTool) for patients admitted to a burn intensive care unit.
Setting
Largest (425-bed) U.S. military hospital, academic medical center and Level 1 trauma center.
Results
- Median exogenous insulin requirements decreased 68.2% after sitagliptin initiation, from 114.3 to 36.3 units/day.
- Incidence of hyperglycemia >180 mg/dL decreased 15% after sitagliptin initiation, from 90.9% to 77.3% of patients.
- Incidence of hypoglycemia <70 mg/dL decreased 33% after sitagliptin initiation, from 13.6% to 9.1% of patients.
- Median time to liberation from intravenous insulin infusion was 3 days after sitagliptin initiation.
Conclusions
The addition of sitagliptin as an adjunct anti-hyperglycemic agent following burn injury is associated with a reduction in exogenous insulin requirements as well as a reduction in episodes of hyperglycemia and hypoglycemia, and allows liberation from intravenous insulin infusion (managed with EndoTool) over a 3-day period.
Authors
Kaitlin Pruskowski; Beth Shield; Craig Ainsworth; Leopoldo Cancio.
Source
Published in International Journal of Burns and Trauma, Volume 10, Issue5, p237-245.
Year
2020
Tags
- Hypoglycemia Reduction
- Hyperglycemia Reduction
- Length of Stay
- Hospital-Acquired Conditions
- Healthcare-Associated Infections
- Surgical Site Infections
- Cost Savings
- Cost Savings|Hyperglycemia Reduction|Hypoglycemia Reduction|Length of Stay
- Time to Target
- Time in Range
- Time on IV Insulin
- Target Goal Attainment
- Mean Glucose Improvement
- Glucose Variability
- Burn Injury
- Cardiac Surgery
- DKA/HHS Management
- Emergency Department
- Induced Hypothermia
- Intra-op Glucose Management
- Obstetrics/Labor & Delivery
- Pediatrics
- Residual Insulin Adjustment
- BG Check Compliance
- BG Test Reduction
- Nursing Satisfaction
- Protocol Adherence
- Provider Satisfaction
- Workflow Improvements
- Nursing Satisfaction|Workflow Improvements