Objective

This retrospective review compares exogenous insulin requirements before and after sitagliptin initiation as well as time to liberation from intravenous insulin infusion (managed with EndoTool) for patients admitted to a burn intensive care unit.

Setting

Largest (425-bed) U.S. military hospital, academic medical center and Level 1 trauma center.

Results

• Median exogenous insulin requirements decreased 68.2% after sitagliptin initiation, from 114.3 to 36.3 units/day.
• Incidence of hyperglycemia >180 mg/dL decreased 15% after sitagliptin initiation, from 90.9% to 77.3% of patients.
• Incidence of hypoglycemia <70 mg/dL decreased 33% after sitagliptin initiation, from 13.6% to 9.1% of patients.
• Median time to liberation from intravenous insulin infusion was 3 days after sitagliptin initiation.

Conclusions

The addition of sitagliptin as an adjunct anti-hyperglycemic agent following burn injury is associated with a reduction in exogenous insulin requirements as well as a reduction in episodes of hyperglycemia and hypoglycemia, and allows liberation from intravenous insulin infusion (managed with EndoTool) over a 3-day period.